It is a 24-hour venue that permits smoking indoors. The 190,000 square foot casino has been expanded multiple times since its opening. It is located on the Tampa Reservation off of Interstate 4, just east of Tampa, Florida. Seminole Hard Rock Hotel & Casino Tampa is a gaming complex and hotel that opened in 2004. ( February 2021) ( template removal help)ĥ223 North Orient Road, Tampa, Florida 33610 Please help to improve this article by introducing more precise citations. This article includes a list of general references, but it lacks sufficient corresponding inline citations.